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"Once Human: Top PvE & PvP Builds, Weapons, Gear"

Author:Kristen Update:Jul 09,2025

In Once Human, your gear and weapon selection are the cornerstones of combat effectiveness. Whether you're clearing corrupted beasts in PvE or engaging in intense PvP battles, a well-optimized build can mean the difference between victory and respawning.

This guide presents four of the most powerful builds currently available in Once Human. Each one is tailored with recommended weapons, gear mods, synergy effects, and playstyle strategies. From AoE damage for crowd control to DoT builds and critical burst setups, these loadouts have been tested extensively in both solo and cooperative gameplay scenarios.

If you're just starting out, be sure to check our Beginner’s Guide for Once Human for a solid foundation before diving into advanced builds.

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Final Tips for Optimizing Your Build

  • Sync weapon effects and mods: Choose gear that enhances your weapon’s elemental or status-based damage output.
  • Keep upgrading: Higher rarity and enhancement levels significantly boost performance—avoid using outdated or under-leveled equipment.
  • Craft backup loadouts: Having alternative builds based on different elements helps counter enemy resistances and adapt to various encounters.

Each build shines in specific situations—whether it's boss fights, wave clear, or quick PvP eliminations. Experiment with each setup, adjust your gear mods accordingly, and switch builds depending on mission type or enemy composition.

For an optimal gaming experience with smooth controls, multi-instance support, and high-performance FPS, consider playing Once Human on BlueStacks. Enjoy lag-free aiming, efficient farming, and seamless inventory handling—all while using a keyboard and mouse setup.